Titan Ceftriaxone sodium injection Review Uses side effects, Dose Precaution In Urdu
Titan Ceftriaxone sodium injection Uses side effects, Dose Precaution In Urdu
Each vial contains dry substance equivalent to 0.25g, 0.5g, 1g or 2g. ceftriaxone as ceftriaxone sodium
Titan Ceftriaxone injection is Uses for severe infections and resistant cases of susceptible gram-positive and gram-negative bacteria cause different following disease.
- Respiratory tract infections
- Urinary tract infections
- Bacterial septicemia
- Bone and joint infections
- Intra-abdominal infections. (Specially typhoid, peritonitis, cellulitis, and abscess)
- Skin & soft tissue infections
- Perioperative surgical prophylaxis
Titan is contraindicated in patients with known allergy to the cephalosporins class of antibiotics.
Ceftriaxone injection Warning & Precautions
- Hypersensitively reactions to cephalosporins, penicillins, or other drugs penicillin-sensitive patients. Therefore allergic reaction to Titan occurs, discontinue the drugs.
- During pregnancy only if clearly needed.
- Nursing mother low concentrations of ceftriaxone are excreted in human milk If clearly need when titan is advised to nursing women.
Side effects Adverse reactions
Titan Injection (ceftriaxone) following adverse reactions.
- Gastrointestinal nausea, and vomiting, diarrhea, stomatitis, and glossitis
- Central nervous system headache and dizziness
- Skin reaction rash pruritus allergic dermatics and urticaria edema erythema multiform and anaphylactic reaction
- Haematologic eosinophilia thrombocytosis leukopenia granulocytopenia and hemolytic anemia.
- Hepatic transient elevations of SGOT or SGPT
- Renal transient elevations of the BUN
- Local side effects in rare cases inflammatory reactions in the vein wall occur after I.V administration. Therefore avoided by slow (2-4 min) injection of the substance intramuscular injection without (lignocaine solution is painful.
Titan Injection INTERACTION
There is no evidence that titan increases renal toxicity of aminoglycosides.
Disulfiram has been No effect after ingestion.
of alcohol subsequent to the administration of titan.
Ceftriaxone does not contain an N-methylthiotetrazoe moiety associated with possible ethanol intolerance and bleeding problems more of certain other cephalosporins.
Titan injection Dosage & Administration:
Adults and children over twelve years: the usual dosage is 1-2 g of the titan (ceftriaxone ) administered once daily (every 24 hours). Titan Injection in severe infections dosage may be Increase to 4.g advise once daily.
Neonates, infants, and children up to twelve years: the following dosage schedule is recommended for once-daily administration neonates (up to two weeks) a daily dose of 20-50 mg/kg body weight therefore not exceed 50mg/kg on account of the immaturity of the infant’s enzyme system. It is not necessary to differentiate between premature and infant born at term.
Infants and children (three weeks to twelve years) a daily dose of 20-80mg/g children with a bodyweight of 50 kg or more than usual adult dosage should be used.
the dosage recommended for adult require no modification in the case of geriatric patients.
Duration of Therapy:
the duration of therapy varies according to the course of the diseases as with antibiotic therapy in the general administration of titan should be continued for a minimum of 48-72 hours after the patient has become afebrile or evidence of bacterial eradication has been obtained.
To prevent postoperative infections in contaminated or potentially contaminated surgery, the recommended approach – depending on the risk of infections – is a single dose of 12 g Titan administered 30-90 minutes prior to Surgery.
Impaired renal and hepatic function:
If the kidney does not work properly, then no need to reduce the dosage of Titan provided hepatic function is intact. Only in cases of preterminal renal failure (creatinine clearance, 10m1/min) Titan dosage should not exceed 2 g daily.
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