Slate Syrup (Cefaclor) – Oral uses , Side effects , Dosage

Drugs medicine

Slate Syrup Cefaclor– Oral uses , Side effects , Dosage

Slate Syrup Cefaclor  – Oral uses , Side effects , Dosage

Composition:
Slate 125/5ml Syrup
Each 5ml of reconstituted suspension contains
Cafaclor Monohydrate USP
Equivalent Cafaclor ………………..125mg

Slate 187MG/5ML Syrup
Each 5ml of reconstituted suspension contains
Cofactor Monohydrate USP
Equivalent Cafaclor ………………..187mg

Slate 250/5ml Syrup
Each 5ml of reconstituted suspension contains
Cafaclor Monohydrate USP
Equivalent Cafaclor ………………..250mg

Slate 50mg/ml paediatric drops
Each 5ml of reconstituted suspension contains
Cafaclor Monohydrate USP
Equivalent Cafaclor ………………..50mg

Slate Syrup Cefaclor- Oral uses , Side effects , DosageSlate Syrup Uses

  • State Syrup is indicated for the treatment of the following types
  • of infections caused by or likely be caused by susceptible organisms.
  • Lower respiratory infections including pneumonia bronchitis and excebations of chronic bronchitis.
  • Upper respiratory infections including pharyngitis, tonsillitis and otitis media.
  • Skin and skin structure infections.
  • Urinary tract infections induding pyelonephritis and cystits.
  • When anti-globulin tests are performed on the minor side,
  • or in Coombs testing of newborns whose mothers have received cephalosporin antibiotics before parturition,
  • it should be recognized that a positive Coombs test may be due to the drug Use in Pregnancy: Category B Safety of cefaclor for use during pregnancy has not been established.
  • Cefaclor should not be used in women of child bearing potential unless, in the judgment of the treating clinician, its use is considered essential to the welfare of the patient and the expected benefits outweigh potential risks Use in Lactation:
  • Small amounts of cefaclor have been detected in mother’s milk following administration of single 500mg doses of cefaclor.
  • Caution should be exercised when cefaclor is administered to a nursing woman Use in Children.
  • Safety and effectiveness of this product for use in infants less than one month of age have not been established

 

Slate Syrup Side effects

Gastrointestinal:

  • The most frequent side effect has been diarrhoea.
  • Nausea and vomiting have been reported rarely.
  • Colitis, including rare instances of pseudomembranous colitis,
  • has been reported in conjunction with therapy with cefaclor

Hepatic:

  • Transient hepatitis and cholestatic jaundice
  • have been reported rarely

Hypersensitivity:

  • Allergic reactions,
  •  urticaria and morbilliform eruptions, 
  • pruritus and positive Coombs’ test.
  • These reactions usually subsided upon discontinuation of the drug.
  • Angioedema and fever have been reported rarely Cases of serum-sickness-like reactions have been reported rarely with the use of cefaclor.
  • These have been reported more frequently in children than in adults

Blood:

  • Eusinophilia
  • thrombocytopenia
  • thrombocytosis
  • hemolytic anemia
  • agranulocytosis and reversible neutropenia

Kidney.

Reversible interstitial nephritis

Superinfection:

  • Genital pruritus,
  • moniliasis or vaginitis

Central Nervous System

  • Rare: Reversible hyperactivity;
  • nervousness
  • insomnia
  • confusion
  • hypertonia
  • dizziness
  • hallucinations
  • headache.

Other Side effects

  • Transitory abnormalities in clinical laboratory test results have been reported, but their clinical significance is uncertain. These include slight elevations in AST, ALT. or alkaline phosphates values; transient fluctuations in leukocyte count, predominantly lymphocytosis in infants and young children; and slight elevations in serum urea or serum creatinine or abnormalities of urinalysis (Haematuria; pyuria)

Slate Syrup DOSAGE AND ADMINISTRATION:

Slate Syrup® is Dosage orally

Adults:

  • The usual adult dosage is 250mg every 8 to 12 hours.
  • For bronchitis and pneumonia, the dosage is 250mg Orally In 3 times daily.
  • For more severe infections or those caused by less susceptible organisms, doses may be doubled (500mg 8 hourly). Doses of 2g/day should not be exceeded For skin and skin structure infections the dosage is 250 mg 2-3 times a day

Children:

  • The usual recommended daily dosage for children with
  • mild to moderate infections is 20mg/kg/day in divided
  • doses every 8 hours (Maximum 1g/day) For streptococcal pharynx gitisitonsillitis
  • and impetigo, 12 hourly administration appears equally effective in
  • more serious infections, otitis media, and infections caused by
  • less susceptible organisms, the recommended dosage is 40mg/kg/day
  • in divided doses every 8 to 12 hours (Maximum 2 g/day). For otitis media,
  • 12 hourly administrations appears equally effective Slate® may be
  • administered in the presence of impaired renal function.
  • In the treatment of beta-hemolytic streptococcal infections.

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