Clomid Tablet - Clomephene Citrat 50mg tablets treat infertility in women

Clomid(Clomephene Citrat 50mg) tablets treat infertility in women

medicine

Clomid Tablet Clomiphene Citrate 50mg) tablets treat infertility in women

Clomiphene Citrate Clomid Tablet Uses

Clomid tablet Used to the treatment of ovulatory failure in women wishing to become pregnant. Clomid is indicated only in patients with ovarian dysfunction. Commonly associated diagnoses include polycystic ovary syndrome, lactation amenorrhea syndrome, psychogenic amenorrhoea, and certain cases of secondary amenorrhoea of undetermined etiology. Additional diagnosis is a post­oralcontraceptive amenorrhea and certain cases of secondary amenorrhea of undetermined etiology.

Pharmacological classification:

Clomid is a diarylethene compound (related to chlorotrianisene and triparanol.) Actions: The ovulatory response to cyclic Clomid therapy appears to be mediated through increased output of pituitary gonadotropins which in turn stimulates the maturation and endocrine activity of the ovarian follicle and the subsequent development and function of the corpus luteum. The role of the pituitary is indicated by increased urinary excretionof gonadotropins and the response of the ovary, as manifested by increased urinary estrogen excretion.

Composition:

Each tablet contains 50 mg clomiphene citrate.

Clomid tablet Clomiphene citrate Dosage

The recommended dose for the first course of Clomid is 50 mg (one tablet) daily for 5 days. WhenTherefore ovulation occurs at this dosage there is no advantage in increasing the dose in subsequent cycles of treatment. If ovulation occurs at this dosage but is not followed by pregnancy, subsequent courses for a total maximum of 6 cycles of Clomid treatment may be administered.

ovulation appears not to have occurred after the first course of therapy, Therefore a second course of 100 mg daily (two 50 mg tablets given as a single daily dose) for five days should be given. If ovulatory menses do not occur, this dose may be repeated for 2 additional cycles but failure to induce ovulation after 3 consecutive cycles at this dosage should constitute an adequate therapeutic trial.

Dose

However, ovulation does occur at this dosage but is not followed by pregnancy, subsequent courses for a total maximum of 6 cycles of Clomid treatment may be administered. Therapy may be started at any time in a patient who has had no recent uterine bleeding; but if progestin-included bleeding is planned, or if spontaneous uterine bleeding occurs prior to the therapy, the course of Clomid should be started on or about the fifth day of the cycle.

Clomiphene citrate Clomid tablet Contraindications

Pregnancy:

Although there is no evidence that Clomid has a harmful effect on the human fetus, Clomid does damage rat and rabbit fetuses when given in high doses to the pregnant animal. Therefore, Clomid should not be administered during pregnancy. To avoid inadvertent Clomid administration during early pregnancy, the basal body temperature should be recorded throughout all treatment cycles, and the patient should be carefully observed to determine whether ovulation occurs. if the basal temperature following all treatment is biphasic and is not followedby menses, the patient should-examined carefully and should have a pregnancy test.

Liver disease:

Clomid should not be given to patients with known liver disease or a history of liver dysfunction. Abnormal uterine bleeding; Clomid should not be given until the cause of bleeding has been determined. It is most important to ensure that neoplastic lesions are not overlooked. Visual symptoms; patients should be advised that blurring or other visual symptoms may occasionally occur during Clomid therapy. The significance of these symptoms is not yet understood. If they occur. clomid should be discontinued and a complete ophthalmological evaluation should be made. No further courses of Clomid should be administered.

Clomiphene citrate Precautions:

careful evaluation and selection of patients and close attention to dosage instructions contraindications: and side effects are mandatory. Since Clomid is indicated only in patients with ovarian dysfunction, other possible causes of infertility should be excluded or treated before giving Clomid. Pelvic examinations should be made before each course_ of Clomid is given.

function on Ovaries

Since Clomid stimulates the ovaries, it may cause abnormal ovarian enlargement due to overstimulation in some patients. With the exception of patients with polycystic ovary syndrome. Clomid should not be given in the presence of an ovarian cyst since further treatment cycle is completed. Patients who complain of *Iv ic pain after receiving Clomid should be examined with care. If enlargement of the ovary occurs, additional courses of Clomid should not be given until the ovaries have returned to Pre-Treatment size, and then a shorter course or smaller dose should be administered Ovarian enlargement and cyst formation that is occasionally associated with Clomid therapy regresses spontaneously within a few days or weeks after discontinuing treatment. Unless surgical indication for laparotomy exists, such cystic enlargement should be managed conservatively.

Multiple Pregnancy 

The incidence of multiple pregnancies is increased when conception takes place during a cycle in which Clomid is given in a large series of closely monitored patients who became pregnant after receiving Clomid, there were 6.9% (165) twins, 0.5% (11) triplets, 0.3% (7) quadruplets, and 0.13% (1) quintuplets. Of these multiple pregnancies, 357 Live infants were ppm of 165 multiple births. After excluding 60 neonatal deaths, 297 survived, including 27 of 61 live infants from trip-let, quadWietliand quintuplet pregnancies in additions, one sextuplet pregnancy has been reported in a patient treated with Clomid. Patients (wd their huslioles) should be advised of the possibility and potential complications of multiple pregnancies associated with domidtheraft.

Clomid Tablet Adverse Reactions:

Side effects are not prominent and infrequently interfere with treatment when the recommended dosage c’ Clomid is given. Side effects are dose-related. being more frequent and more severe when higher doses of Clomid are administered, the more common side effects are hot flushes, abdominal discomfort (distension, bloating, pain and soreness). Ovarian enlarge and visual blurring. The vasomotor symptoms resembling menopausal hot flushes are not usually severe and disappear soon after, treatment is discontinued. Abdominal symptoms are most often related to ovulatory (Mittelschrnerz) or premenstrual phenomena, or to ovarian enlargement. At the recommended dosage, the normal variation in ovarian size may be exaggerated. The rare instance of massive ovarian enlargement and rupture of a lutein cyst with hemoperitoneum have been reported

Visual Symptoms

Visual symptoms described usually as “blurring” or spoils or flashes (scintillating scotomata), increase in incidence with increasing total dose and disappear within a few days or weeks after Clomid is discontinued. These symptoms appear to be due to intensification and prolongation of afterimages. Symptoms often first appear or are accentuated with exposure to a more brightly life environment. While measured visual acuity has not generally been affected, one patient taking 200 mg daily developed visual blurring on the seventh day of treatment which progressed to severe diminution of visual acuity by the tenth day.

prolonged Medicine therapy

No other abnormality was found, and the visual acuity returned to normal on the third day after treatment was stopped. One patient treated during clinical studies developed scotomata during prolonged This medicine administration, which disappeared by the 32nd day after stopping therapy. In a 34-years-old patient who had taken 3 courses of Clomid, slit-lamp microscopic examination showed a mild amount of posterior cortical subcapsular opacity in each eye. Ophthalmoscopic examination revealed normal findings. The ocular diagnosis was posterior cortical “senile” cataracts. Ophthalmologically definable scotomata and retinal cell function (electroretinographic) changes have also been reported.

Clomid Tablet Clomiphene Citrate Side effects

  • Other less frequently reported symptoms included
  • nausea or vomiting,
  • increased nervous tension,
  • depression,
  • fatigue,
  • dizziness
  • or lightheadedness,
  • insomnia,
  • headache,
  • breast soreness,
  • heavier menses,
  • intermenstrual spotting
  • weight gain,
  • urticaria and allergic dermatitis,
  • increased urinary frequency and moderate reversible hair loss.

                                                                                                                                                                  Clomiphene research

Defects at birth, have been reported in 58 infants from 2,369 delivered pregnancies in mothers treated with Clomid. Four of the infants were in the abortion/stillbirth category 14 were from multiple pregnancies, and the remaining were single births. The defects have included. Down’s syndrome (5 infants), congenital heart lesions (8 infants), microcephaly (2 infants), harelip and cleft palate (2 infants). hypospadias (3 infants), undescended testes (2 infants), club foot: (4 infants) gastrointestinal malformation (4 infants), congenital hip (2 infants), and polydactyly (both of twins).

 

Eight of the totals of 58 infants were born to 7 of 158 mothers who received (inadvertently) a course of Clomid during the first 6 weeks after conception.

Clomid, when given continuously for prolonged periods, may interfere with cholesterol synthesis. Serum from patients treated in this way appears to have elevated desmosterol levels. In patients taking recommended doses of Clomid serum sterol patterns are not significantly altered.

Clomid tablet In Liver And Renal function 

Bromosulphothalien (BSP) retention of greater than 5% has been reported in 32 of 141 patients in whom it was measured. Other liver function tests were usually non-Renal. Retention was usually minimal unless associated with prolonged continuous Clomid administration or with apparently unrelated liver disease. In some patients, preexisting BSP retention decrease even though Clomid therapy was continued. One patient developed jaundice on the 14th day of Clomid therapy. Liver biopsy revealed bile stasis without evidence of hepatitis. Clomid has not been reported to cause significant abnormality in the hematopoietic or renal system, the protein-bound Iodine or in serum cholesterol.

 

Clomiphene Therapeutic Use:

It is indicated for the treatment of anovulation in carefully selected infertile women who wish to become pregnant. In such patients, approximately 70% will ovulate and (provided that there is no other cause of infertility in them or in their husbands) about 30% will become pregnant, it is worthwhile to note that the data from which these percentages were derived included patients who were single and some who either did not desire pregnancy at the time of treatment or had impediments to achievement of pregnancy other than ovulatory dysfunction. therefore Ovulation most often occurs from 6-12 days after a course of Clomid. With this in mind, coitus should be timed to coincide with the expected time of ovulation.

Clomiphene indication

Although there is no evidence of a “carry-over effect” of Clomid, persistent

spontaneous ovulation menses have been noted after Clomid therapy in some

patients. Good levels of endogenous estrogen estimated from vaginal smears,

endometrial biopsy, an assay of urinary estrogen, or from bleeding in response to

progesterone is a favorable prognosis for treatment with Clomid, but reduced

estrogen levels do not always rule out the possibility of successful therapy,

Clomid therapy is ineffective in patients in whom primary pituitary or ovarian

failure precludes the possibility of stimulating normal function.

 

Clomiphene Tablet Ovulatory patients

Some anovulatory patients that appear to respond to this medicine but either

do not actually ovulate or whose luteal phases are so short that the opportunity

to conceive is limited, may benefit by having following Clomid courses, injections

of human chorionic gonadotropin (HCG) at about the expected time of ovulation.
Infertile patients with polycystic ovary syndrome who have not responded to

wedge resection of the ovary may respond to Clomid. CLOMID

(Clomiphene citrate tablets), the first fertility drug. The world of difference

to thousands of childless couples

 

Clomephene Tablet Citrate  Uses

کلومیڈ گولیوں کو ہم زنانہ مختلف بیماریوں میں استعمال کراتے ہیں
حیض کو ریگولر کرتی ہے اور اوانڈا کا اخراج کرتی ہے

جن فیمل کو پی سی او ایس کا مسئلہ ہوتا ہے

کلومیڈ ٹیبلٹ کلومیفینی سائٹریٹ 50 ملی گرام)
گولیاں خواتین میں بانجھ پن کا علاج کرتی ہیں Chomephene Citrate Clomid Tablet استعمال کرتا ہے

کلومڈ ٹیبلٹ حاملہ ہونے کی خواہش رکھنے والی خواتین میں
اوولٹریٹری ناکامی کے علاج کے لئے استعمال ہوتا ہے۔


کلوماڈ صرف اوراجنوری dysfunction کے مریضوں میں اشارہ کیا جاتا ہے۔
عام طور پر وابستہ تشخیص میں پولیسیسٹک انڈاشی سنڈروم ،
دودھ پلانے والے امینووریا سنڈروم ، سائیکوجینک امینووریا ،
اور غیر متعین ایٹیالوجی کے ثانوی امینوروہیا کے کچھ معاملات شامل ہیں۔
ایک اضافی تشخیص پوسٹلورکنٹریسیپٹ امینووریا ہے ،
اور غیر متعین ایٹولوجی کے ثانوی امینوریا کے کچھ معاملات۔ دواسازی کی درجہ بندی: کلومائڈ ایک ٹریریلیتھلین مرکب ہے
(کلورٹریانیسن اور ٹریپرانول سے متعلق ہے۔) عمل:
چکولک کلومیڈ تھراپی کا بیضوی ردعمل پٹیوٹری گوناڈوٹروپن
کی بڑھتی ہوئی پیداوار کے ذریعہ ثالثی ہوتا ہے جس کے نتیجے
میں ڈمبگرنتی پٹک اور اس کے نتیجے میں ہونے والی نشوونما
کی پختگی اور انڈروکرین سرگرمی کی حوصلہ افزائی ہوتی ہے۔
کارپس luteum کی تقریب. پٹیوٹری کے کردار کی نشاندہی
گونڈوٹروپن کے بڑھتے ہوئے پیشاب کے خارج ہونے اور انڈاشیوں
کے ردعمل سے ہوتی ہے ، جیسا کہ پیشاب کے ایسٹروجن اخراج میں اضافہ ہوتا ہے۔

تشکیل: ہر گولی میں 50 ملی گرام کلومیفین سائٹریٹ ہوتا ہے۔ کلومیڈ گولی کلومیفینی سائٹریٹ

خوراک کلومیڈ Tablet Clomid  Clomiphene

کے پہلے کورس کے لئے تجویز کردہ خوراک 5 دن کے لئے


روزانہ 50 ملی گرام (ایک گولی) ہے۔ جب اس مقدار میں بیضہ ہوتا ہے
تو علاج کے بعد کے چکروں میں خوراک میں اضافے کا کوئی فائدہ نہیں ہوتا ہے۔
اگر اس مقدار میں بیضہ ہوتا ہے لیکن حمل نہیں ہوتا ہے تو ،
کلومیڈ علاج کے کل زیادہ سے زیادہ 6 سائیکل کے ل courses بعد کے
کورسز کا انتظام کیا جاسکتا ہے۔ ovulation کے تھراپی کے پہلے کورس کے بعد نہیں ہوا ہے ،
لہذا ، روزانہ 100 ملی گرام (ایک دن کی ایک خوراک کے طور
پر دو 50 ملی گرام گولیاں) کا دوسرا کورس پانچ دن تک دیا جانا چاہئے۔
اگر ovulatory حیض نہیں ہوتا ہے تو ، اس خوراک کو 2 اضافی سائیکلوں
کے لئے دہرایا جاسکتا ہے لیکن اس خوراک میں لگاتار 3 سائیکلوں کے بعد
ovulation کو دلانے میں ناکامی کا مناسب علاج معالجہ تشکیل دینا چاہئے۔ تاہم ، ovulation کے اس خوراک پر پایا جاتا ہے لیکن حمل کے بعد نہیں ہوتا ہے ،
کلومیڈ علاج کے زیادہ سے زیادہ 6 سائیکلوں کے ل for بعد کے کورسز کا انتظام کیا جاسکتا ہے۔ تھراپی کسی بھی وقت کسی مریض میں شروع کی جاسکتی ہے جس کو حالیہ بچہ دانی نہیں ہوا ہے۔ لیکن اگر پروجسٹن شامل خون بہہ رہا ہے اس کا منصوبہ بنایا گیا ہے ، یا اگر تھراپی سے پہلے بے ساختہ یوٹیرن سے خون بہہ رہا ہو تو ، سائیکل کے پانچویں دن یا اس کے قریب کلومائڈ کا کورس شرو
ع ہونا چاہئے۔

 

Clomid Tablet

 

Clomiphene Tablet Side effects

Nausea

vomiting

 ویجائینل بلیڈنگ
دست لگ سکتےہیں.
آنکھوں کے سامنے اندھیرا ہو سکتاہے.
سر درد ہو سکتا ہے.
سینے میں سوجن ہوسکتی ہے.
اس سے بچے زیا دہ پیدا ہوسکتے ہیں

اوری کا سائزبڑھ سکتا ہے

 

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